Scientist II - Preformulation / Solid-State Chemistry
Target PR Range: 45-55/hr
*Depending on experience
- Conduct preformulation studies to characterize the physicochemical properties of drug candidates (e.g., solubility, preclinical formulation (solution/ suspension), pKa, log P/D, hygroscopicity, stability).
- Perform solid-state characterization using techniques such as XRPD, DSC, TGA, microscopy, FTIR, SEM, bulk/tapped density, contact angle, and solid-state NMR.
- Under the guidance of a senior scientist, conduct salt, cocrystal, and polymorph screening to enable selection of optimal drug substance forms for development.
- Conduct compatibility and excipient screening studies to support formulation development.
- Work closely with formulation scientists to generate data guiding solid oral dosage form development.
- Analyze, interpret, and document experimental data, ensuring high-quality technical reports.
- Maintain laboratory notebooks and comply with all laboratory safety requirements.
- Present data and findings in team meetings and contribute to scientific discussions.
- PhD/M.S. in Pharmaceutical Sciences, Chemistry, Materials Science, or related field with 0-2 years of relevant industry experience; or B.S. with 3-5 years of relevant experience in preformulation or solid-state chemistry.
- Hands-on experience with solid-state analytical techniques (XRPD, DSC, TGA, SEM, PLM, Surface area, True density, FTIR, HPLC, NMR spectroscopy).
- Familiarity with solubility, dissolution, and stability testing of drug candidates.
- Understanding of solid-state form screening (salt, cocrystal, polymorph).
- Experience with data analysis and documentation in regulated environments.
- Proficiency with scientific software and instrumentation for material characterization.
- Strong problem-solving skills and scientific curiosity.
- Excellent organizational and documentation practices.
- Ability to work independently as well as in a multidisciplinary team environment.
- Effective written and verbal communication skills.
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